nature.com · Jun 3, 2026 00:00 UTC

Development of 1-(substituted benzofuran-2-yl)-3-(halogen-substituted phenyl)prop-2-en-1-ones as potent, reversible, and selective MAO-B inhibitors for Parkinson’s Disease

Ten halogenated benzofuran derivatives (BF1–BF10) were synthesized and evaluated for their inhibitory activity against monoamine oxidase isoforms. All compoun...

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journals.plos.org · Jun 2, 2026 18:08 UTC

PepAnno: A structure-aware deep learning framework for bioactive peptide prediction, structural visualization, and physicochemical profiling

Author summary PepAnno is an integrated web server developed to advance the study of bioactive peptides—small yet versatile molecules with significant therape...

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arxiv.org · Jun 2, 2026 04:00 UTC

[2606.01461] Genotype-Conditioned Molecular Generation via Evidence-Grounded Multi-Objective Latent Perturbation in Diffusion Models

Abstract page for arXiv paper 2606.01461: Genotype-Conditioned Molecular Generation via Evidence-Grounded Multi-Objective Latent Perturbation in Diffusion Model...

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jmir.org · May 29, 2026 14:53 UTC

From Virtual Molecules to Clinical Trials: How AI Is Reshaping Preclinical Drug Discovery

Pharmaceutical development is typically a long and arduous process, but advances in artificial intelligence may help streamline each stage of this pipeline. In ...

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arxiv.org · May 29, 2026 04:00 UTC

[2605.28862] Molecular Lead Optimization via Agentic Tool Planning

Abstract page for arXiv paper 2605.28862: Molecular Lead Optimization via Agentic Tool Planning

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